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Have you ever wanted to figure something out so desperately for the good of others, but realize that in order to find the answer you would have to skirt moral, human ethics to incredible degrees?

Welcome to the world of being a scientist. You are always hungry for more information, but have to realize there is a line that you cannot cross when experimenting, especially with human test subjects.

But that doesn't stop 'em from dreaming.


u/illuseyourusername asked:

(Serious) Scientists of Reddit, what is something you desperately want to experiment with, but will make you look like a mad scientist?

Here were some of those answers.


Psychopath Through The Ages

Giphy

I want to take DNA from infamous serial killers like Dahmer or Albert Fish or the like, clone them, then have the baby raised in a normal, supportive, loving family.

I'd study the kids all through adulthood to see how much is nurture and how much is nature.

RecalcitrantJerk

There's a guy who did a TED Talk, found out by accident that he has the brain of a serial killer (brain scan). Talked about the character qualities he has that fit the bill, family history and all that.

https://www.smithsonianmag.com/science-nature/the-neuroscientist-who-discovered-he-was-a-psychopath-180947814/

lonequack

Your Own Personal Ecosystem

I want to do a long term case study on children's Microbiome. It would start with samples of their mothers microbiome, and then when the child is first born get a sample of theirs, compare it, and continue comparing the two samples throughout breast feeding vs. bottle feeding. Also get a detailed comparison of how the microbiome changes after vaccinations, sickness, antibiotics.

I would basically study every single poop this child has, their eating habits, their health conditions, any medications, vaccinations, etc. for years.

But people want privacy, and most wouldn't want to commit to keeping such accurate accounts of their children's food/health/activities, so it's likely that even if I did this study it would be difficult to prove all variables were accounted for. And with all the variability I would need many, many children.

The end goal is to see how our microbiome changes throughout your childhood, and note when you may be more susceptible to things depending on the type of microflora you have. Everyone has a different ratio, so essentially if we can harness the individuals capability of unique flora we could find a whole new way to tackle illnesses and preventatives for sicknesses that would have significantly less side effects than many other medications.

This idea stems from others studying the microbiome, and finding that certain ratios of microflora can cause you to get over illnesses quicker when combined with the right medicine, and also help digestive tracks regulate better. But so far these tests are being done with cancer patients. I think if we're able to see how children are effected it may bring less possibilities of cancer and other illnesses down the road, as well as a faster recovery time.

BlondeStalker

Ethics

I'm a physician and I would love to see how far the Placebo Effect really goes.

For those who are not familiar, the Placebo Effect is an unexplained phenomena where people who take medications that aren't real, but they believe are real, have an actual, measurable effect on their illness. People with depression who take sugar pills report feeling happier. People with pain who take sugar pills report a decrease to their pain etc.


I've seen even crazier ones where people think they are having surgery for their bad knee...but the docs just put them under, make an incision on their knee, do nothing, sew them back up and patients report improvement to their bad knee.

So part of me just wants to explore this to its full extent. Can we treat chronic illnesses like arthritis, lupus and bipolar disorder with just placebos? What about viral illness? Can you imagine if someone's HIV viral load decreased while they're eating Skittles thinking its a new miracle drug?


PhillipLlerenas

Call Of The Wild

Experiments with social isolation intrigue me. Raise a child with no language and see what happens. No contact. Wild children give us some insights, but also a sample of the kind of trauma this can produce. Completely and undeniably unethical. Incredibly cruel. But sooooo intriguing!!

Pyrocephalus-rubinus

Heat Vision

I want to work on genetically modifying the genes that control our active cones in our eyes. Specifically I want to try to activate a tertiary cone in the eyes of dogs so that they can see infared light just like snakes can.

In simpler terms, we could make rescue dogs that have infared vision to help locate missing people or recover people in natural disasters.

In even simpler terms I want to make heatseeking dogs.

CleanableYetti

In The Way

I wouldn't say "mad scientist", but medical privacy laws get in the way of a LOT of incredibly useful research. Everything has to be so de-identified and confidential that it makes doing any sort of large-scale statistics nearly impossible. You have to make a ton of assumptions because you can't know many details.

If I had full access to everyone's medical records, we could probably fix a whole lot.

scottevil110

When Mad Lightning Strikes

The typical discovery and clinical testing pipeline of a pharmaceutical looks something like this:

cell culture > rodent models > other animals (primates, rabbits, etc.) > humans

If at any step the drug fails the test (either for toxicity or efficiacy), the potential drug is nixed. And this process of discovery and clinical testing can take up to 10 years at the cost of billions of dollars.

What happens if your model systems can't fully recapitulate the human disease phenotype? So what happens if you've got a drug that might work really well in the human, but we never know, because it gets trashed because there's no response in the mouse model?

Now I completely understand the ethical concerns with testing on human subjects from the get go, but if you asked me to don my mad scientist lab coat and goggles, I'd try to push for earlier testing on human subjects.

bigtcm

Violating The Oath

I'd never do the experiment, but it's hard to overstate how helpful it would be to have large-scale, longitudinal data on how different chemotherapeutic drugs/drug cocktails affect the evolutionary trajectory of tumors.

The problem is that in order to study it, you'd need to:

  1. Give a large number of people experimental or substandard care, which is highly unethical.
  2. Perform serial surgeries even when they aren't medically necessary in order to collect tissue samples from the tumors, and since every surgery carries with it some risk this is also highly unethical.

Ichor

Use the milk from orb spiders (they mix the DNA of orb spiders with goals at UWyoming) to build a better dental filling. They'd hypothetically last exponentially longer, would bond to tooth as an organic substance, and are stronger that Teflon. It would also be minimally invasive as to set the groundwork for more invasive medical applications such as knee replacements. If you fund me I know the orb goat and dental guys.

StarbuckXMachina

Many Moooooooore

Giphy

I'd like to raise babies in various planned conditions such as:

  • Without any adult human interaction
  • Without language
  • Indoors only
  • With different concepts of a family unit
  • With different concepts of gender roles

And many more!

NewClayburn

Image by Clker-Free-Vector-Images from Pixabay

Have you ever been reading a book, watching a movie, or even sitting down for a fantastical cartoon and began to salivate when the characters dig into some doozy of a made up food?

You're not alone.

Food is apparently fertile ground for creativity. Authors, movie directors, and animators all can't help but put a little extra time and effort into the process of making characters' tasty delights mouthwatering even for audiences on the other side of the screen.

Read on for a perfect mixture of nostalgia and hunger.

AllWhammyNoMorals asked, "What's a fictional food you've always wanted to try?"

Some people were all about the magical foods eaten in the magical places. They couldn't help but wish they could bite into something with fantastical properties and unearthly deliciousness.

Nutritious

"Enchanted golden apple" -- DabbingIsSo2015

"The Minecraft eating sounds make me hungry" -- FishingHobo

"Gotta love that health regeneration" -- r2celjazz

"Pretty sure those are based off the golden apples that grant immortality. Norse mythology I think?" -- Raven_of_Blades

Take Your Pick

"Nearly any food from Charlie and the Chocolate factory" -- CrimsonFox100

"Came here to say snozzberries!" -- Utah_Writer

"Everlasting Gobstoppers #1, but also when they're free to roam near the chocolate river and the entire environment is edible." -- devo9er

Peak Efficiency

"Lembas" -- Roxwords

"The one that fills you with just a bite? My fat a** would be making sandwiches with two lembas breads and putting bacon, avocado and cheese inside. Then probably go for some dessert afterwards. No wonder why those elves are all skinny, eating just one measly bite of this stuff." -- sushister

Some people got stuck on the foods they saw in the cartoons they watched growing up. The vibrant colors, the artistic sounds, and the exaggerated movements all come together to form some good-looking fake grub.

The One and Only

"Krabby patty 🍔" -- Cat_xox

"And a kelp shake" -- titsclitsntennerbits

"As a kid I always pretended burgers from McDonalds were Krabby Patties, heck from time to time I still do for the nostalgia of it all. Many of my friends did the same thing." -- Thisissuchadragtodo

Cheeeeeeeeese

"The pizza from an extremely goofy movie. The stringy cheese just looked magical lol" -- ES_Verified

"The pizza in the old TMNT cartoon as well." -- gate_of_steiner85

"Only bested by the pizza from All Dogs Go to Heaven." -- Purdaddy

Get a Big Old Chunk

"Those giant turkey drumsticks in old cartoons that characters would tear huge chunks out of. Those things looked amazing, turkey drumsticks in real life suck and are annoying to eat."

-- Ozwaldo

Slurp, Slurp, Slurp

"Every bowl of ramen on any anime, ever." -- Cat_xox

"Studio Ghibli eggs and bacon" -- DrManhattan_DDM

"Honestly, any food in anime. I swear to god half the budget no matter what the studio goes into making the food look absolutely delicious." -- Viridun

Finally, some highlighted the things that aren't quite so far-fetched, but still far enough away that it's nothing we'll be eating anytime soon.

That tease can be enough to make your mouth water.

What's In It??

"Butter beer" -- Damn_Dog_Inappropes

"came here to say this. i was pretty disappointed with the universal studio version which was over the top sweet. it was more of a butterscotch root beer. i imagine butter beer to be something more like butter and beer, which wouldn't be crazy sweet, but would have a very deep rich flavor" -- crazyskiingsloth

Slice of the Future

"The microwave pizzas in back to the future two" -- biggiemick91

"I've been fascinated with those for years! They just look so good!" -- skoros

As Sweet As They Had

"The Turkish Delight from Lion Witch & Wardrobe. The real ones I had weren't bad but nothing special." -- spoon_shaped_spoon

"Came here to say this. I know it's a real thing, but I always imagined that it must have been amazing to betray your siblings over." -- la_yes

"You're used to freely available too sweet sweets. For a WW2 era schoolkid, it would have represented all the sweets for an entire year." -- ResponsibleLimeade



Here's hoping you made it through the list without going into kitchen for some snack you didn't actually need.

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