Spencer Platt/Getty Images, @vinkell/Twitter

In 2015, drug manufacturer Pfizer discovered that one of their drugs used to treat rheumatoid arthritis could significantly lower the risk of Alzheimer's disease.


Pfizer sat on that information and did nothing about it.

According to an explosive investigative report by The Washington Post, Pfizer deliberately chose not to pursue further research after finding out that their anti-inflammatory drug Enbrel (etanercept) could reduce Alzheimer's by 64%.

The Post obtained company documents that stated:

"Enbrel could potentially safely prevent, treat and slow progression of Alzheimer's disease."

So why would Pfizer withhold such potentially life-changing information?

It all boils down to exorbitant cost.

A clinical trial to determine Enbrel's effect on those at risk of Alzheimer's could cost upwards of $80 million.




Pfizer defended their decision to avoid the trial due to an assumption that the size of the large molecules would be too large to reach the brain.

They also wanted to prevent outside researchers from reaching a "dead-end path."

Another speculation for the drug company's decision to forgo with a trial has to do with Enbrel's now-expired 20-year patent.

A former executive told The Post:

"It probably was high risk, very costly, very long-term drug development that was off-strategy."




This user strongly believes that Pfizer has an obligation to make their findings public.






The connection between Alzheimer's disease and rheumatoid arthritis is still unknown.

RA is an auto-immune disease caused by the tumor necrosis factor-alpha, (TNF) – a cell signaling protein involved in systemic inflammation.

Richard Chou, MD, PhD found that in people over 65 years of age, the prevalence of Alzheimer's disease was more than twice as high among those with RA as in those without it, according to the study published in CNS Drugs.

Chou and his team of researchers at Dartmouth and Harvard discovered that the use of Enbrel reduced the risk of Alzheimer's based on data from insurance claims, the same way Pfizer came to a similar conclusion.

At the time, Chou told The NY Times that:

"We've identified a process in the brain, and if you can control this process with etanercept, you may be able to control Alzheimer's, but we need clinical trials to prove and confirm it."

Christmas is upon us. It's time to get those Christmas present lists together.

So... who has been naughty and who has been nice?

Who is getting diamonds and who is getting coal? Yuck, coal. Is that even a thing anymore? Who even started that idea?

There has to be some funnier or more "for the times" type of "you've been naughty" stocking stuffer.

I feel like the statement coal used to make is kind of last century at this point.

Apparently I'm not alone in this thinking.

Keep reading... Show less

I admit, I love my stuffed animals. They're the best.

Some of them have been with me for years and I have them proudly displayed in different spots around my apartment. And when I've packed them for a move, I've done so with all the tender loving care I can muster.

What is it about them that stirs up these feelings?

Believe it or not, it's quite possible to form emotional attachments to inanimate objects!

Keep reading... Show less
Nik Shulaihin/Unsplash

They say your 30's hits different, like one day you're young a hopeful and the next day you're just WAY too old for this.

What is the "this" you're suddenly too old for?

No idea. It's different for everyone, but make no mistake, it'll happen to you too.

Maybe it already has?

Giphy

Keep reading... Show less

Do all mothers go to the say mom school or something? Because they seem to share the same advice or go on the same platitudes, don't they?

Here's an idea.

Maybe they're just older, have more experience, and are trying to keep us from being dumbasses in public. At least, that's what I think.

I'm definitely grateful for my mother's advice—it's saved me more than once—and it seems many out there are too. And they all seem to have heard the same things from their mothers, too.

Keep reading... Show less