Medical Professionals Recount The Rarest Treatment They've Ever Had To Administer
You might have friends who debate the merits of eastern medicine versus western medicine. Modern sciences stacked up against thousands of years of natural remedies. While both sides carry multitudes of legitimate arguments, it's possible both sides would agree that all of the below treatments are a little out there.
Reddit user, u/1234byfeist, wanted to know:
Check. Double Check. Check Fifteen More Times.Giphy
It was many years ago and I was working with end-stage cancer patients. This one woman, who began her treatment outside of the United States, was given a mixture of cocaine, heroin, alcohol, morphine, phenothyazine and some other antiemetics. It was specially made into a liquid and imported from somewhere in Europe. I remember this med so vividly because it's not everyday you give someone heroin. I think it was called something like Bromton Cocktail and the lengths that were gone to to check out and administer a dose of that stuff - we're talking who's got the nuclear codes type of system. I have to admit though, it worked like magic.
The Costs Add Up Over A Year
The rarest medication I have administered is eculizumab (Soliris) which is used for PNH. A single dose costs around $20,000 and it is administered every two weeks at a cost of around $540 000 per year. It is delivered by armoured courier and the patients do get a 24h concierge they can always contact.
The patient told me it was expensive, and being aware of very expensive biologics I told her, "Yes, many of the new monoclonal antibodies are very expensive and can cost up to $20 000 per year."
She corrected me, that it cost $20 000 per dose. I didn't believe her but while organizing the infusion I figured I better read up on a drug I was administering for the first time and, yup, $20 000 a dose--26 doses a year--for the rest of her life.Aquamans_Dad
Speak Your Truth To Yourself
Sodium thiopental-truth serum.
In residency, someone had a conversion disorder in a movie theater (I know, way back when it was a normal thing to do). The entire place cleared out after the movie, his buddies are talking and realize he's not getting up. He finally tells them he is paralyzed and can't move.
Medics brought him in, he's laying in the gurney in the sitting position, like he's an astronaut. I walk in the room and think to myself, whaaat the f---ck. I go ahead and take his history, go back and present him to my attending. Attending asks me what I want to do. I'm at a serious loss here, I have no f-cking clue other than wait him out, nobody's core is that strong. He says we should give him thiopental.
Of course I say lets do it. We go in with just us and a nurse, he turns the lights off, the nurse pushes the meds. My attending proceeds to walk this guy down with confidence and empathy, like he's walking him through the worst lsd trip ever.
Sure enough, my attending asks him to realize that his arm is attached to his chest which is attached to his back which connects to his neck which connects to his brain. He tells the guy, now is the time to move your arm. The kid moves his f-cking arm! AMAZING. After a bit longer the kid is lying flat. Soon enough he's up a moving. Craziest sh-t I saw that year. Emergency medicine, still not dull 10 years later.spewgene
Activated protein c. Can't remember exactly but it was about £50k a dose. Used in severe last ditch sepsis treatment. Not a vial you want to drop.
Artificial Body Parts
It's been a few years so I might butcher the name... Alpha-1 antitrypsin proteinase inhibitor? I've only given it to two patients but they had to get it regularly. It's a synthetic version of a protein, I think, that is made in the liver and usually inhibits the action of a particular enzyme in the lungs that breaks down tissue to ensure that dead cells don't interfere with lung function or something like that.
But in these patients, either the protein was being made wrong in such a way that it couldn't pass through the bile duct and escape the liver, or it just wasn't being made. Without an inhibitor, the enzyme just keeps breaking down tissue, and that causes emphysema. These patients had to get this medication once a week, for the entirety of their lives, but they're the only patients I ever heard of that needed it.
I was only a Hospital Corpsman in the Navy at the time, not even a licensed nurse; I only have a surface understanding of what exactly was going on, so sorry if I got anything wrong in the explanation. This was administered in an ambulatory infusion clinic at a naval hospital; I administered it and had to understand it to anticipate any potential side effects and double check dosing and rate but an actual doctor created the treatment plan and everything.
Space Age MedicineGiphy
Methylene blue. I gave it to a girl who tried overdosing on Orajel. The active ingredient is benzocaine which caused her to develop a methemoglobinemia, treated with the blue drug. It truly is an artificial looking bright blue and I gave it to her in her IV.
Redirect That Blood Flow
Viagra for patient with pulmonary hypertension, only serve it once.
Other than that, thalidomide for anti nausea which is very rare and anti venom for snake bite.
One dose per eye, USD $425,000.00 per eye.
THE MOST EXPENSIVE TREATMENT IN THE WORLD.
What does it treat?
The answer to tour question is very technical, but here it goes.
LUXTURNA is for individuals with an inherited retinal disease caused by mutations in both copies of the RPE65 gene and who have enough remaining cells in the retina
A gene is the basic unit of hereditary information that is passed on to a child from their parents. Typically, every person has 2 copies of a gene, one from each parent. In the case of RPE65 gene mutations, both of the genes passed onto the child were mutated.
There are many inherited retinal diseases
For example, Leber congenital amaurosis and retinitis pigmentosa are two inherited retinal diseases. These are clinical diagnoses that are not based on mutations in specific genes, such as mutations in both copies of the RPE65 gene. To get a genetic diagnosis, you will need a genetic test.
LUXTURNA is a one-time gene therapy for each eye
Gene therapy is a method for treating a genetic disease. One approach to gene therapy is delivering a new or functional gene into a cell.
LUXTURNA works to restore the visual cycle.
The visual cycle is a process that allows you to see. LUXTURNA provides a working RPE65 gene to act in place of a mutated RPE65 gene. This working gene has the potential to make the visual cycle work properly again.
So, There's A Wrong Way To Take This?
I had a woman who was on Ziconotide, which is an analgesic derived from Cone Snail venom. If it isn't administered correctly (through the spine), it causes hallucinations.
Pharmacist here and leeches. We use them to keep blood flowing if you get a finger or ear or something cut off and sewn back on.
Nope. Too Much. Leaving.
Maggots. We had a drug addict come in who had let an infection go so long in his arm from repeated needle usage that all our attempts to clean it failed. We ended up using maggots to eat away the dead tissue, while leaving the healthy tissue intact. Dude just had an open wound full of maggots loosely covered in some gauze for like... several days.
The worst part is always having to collect them afterward.
The medication most people are shocked by is cocaine hydrochloride. Yep. Cocaine. It's a good vasoconstriction agent, and topical anesthetic.
Everyone, You Know The Words To "We Didn't Start The Fire!"
In 15 years of hospital pharmacy, I've twice had occasion to dispense Thalidomide. It's used as an end-stage anti-nausea med, and comes very carefully packed, with all sorts of warnings about not coming near it if pregnant, and even has little pictures of Thalidomide babies.
A poop/fecal transplantation. At my first internship during nursing school, there was a patient with a bowel infection caused by clostridium difficile. A few months before he got treated with broad-spectrum antibiotics for a pneumonia, which caused the infection. They tried other treatments to cure the infection, but nothing worked. Eventually, the patient got accepted in a clinic trial for a fecal transplant. One of his kids was the poop donor. After the transplantation the infection actually cleared up!
Getting Crunk In The ERGiphy
Vodka, because of methanol poisoning.
I was going to say the most surprising thing I saw in the fridge in the med room was a can of beer. Labeled (prn qd) and chilled for the patient.
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History is made on a daily basis.
Indeed, there is little more exciting than having witnessed the accomplishments of people like Barack Obama, Stacey Abrams, and Greta Thunberg knowing that they have firmly reserved a space for themselves in history books.
Of course, most of the people who paved the way to make the world what it is today have long since passed away.
Not all of them, though!
It may surprise you to learn that there are people who made an indelible impression on history who are still much alive today.
Some of whom even continue to make a difference to this very day
Redditor enginearz was eager to hear about historical figures people were surprised to learn were still alive, leading them to ask:
"What famous person from history is still alive?"
Forever Leaving His Name In Science
"He's the only currently living man with an element on the periodic table named after him."- snowflake247
Quite The Story To Tell
"Last human to hold the title of Tsar, as leader of the Kingdom of Bulgaria."
"He was exiled along with his family when the Soviets invaded Bulgaria in 1944."
"In 1990, after the fall of the Soviet Union, Simeon returned from exile to Bulgaria and July 2001, was democratically elected prime minister."
"The private citizen is now 85."- DirectionNew5328
Making Nature Cool For Decades
"David Attenborough."- random_username_96You Can Do It Uoftartsci GIF by U of T Faculty of Arts & ScienceGiphy
The Fought For Freedom And Justice
"The last surviving airman of the battle of Britain."
"He is 103 years old."
"He helped with the liberation of Auschwitz."
"He is 99 years old."
"He was a prosecutor at the Nuremberg trials."
"He is 102 years old."- Ashtar-the-Squid
"The last living member of the german anti-nazi resistance group 'White Rose".
"Most well-known members were the sibling Sophie and Hans Scholl, who were executed by the Nazis when they were identified."- ChrisTinnef
The One Who Made One Giant Leap For Mankind
"Buzz Aldrin, and I’m not even American."- mukaltinState Of The Union Salute GIF by MSNBCGiphy
Opening Doors For So Many Others
"She was one of the first black kids to go to an all-white school."
"There is a famous picture of that first day."- mumwifealcoholic
He Continues To Surprise Us
"Ozzy Osbourne."- CaptinDerpI
Admirably Defying So Many Odds
"98 years old."- Back2BachJimmy Carter Drilling GIF by GIPHY NewsGiphy
We've Still Got Two Out Of Four
"Paul and Ringo"- HMKingHenryIX
Inching Close To The Big One Double Oh...
And Still Practically Perfect In Every Way
"Julie Andrews."- aslrulesjulie andrews snap GIFGiphy
Who Could Forget About Dick Van Dyke ?!?!?!?!
"Everyone just forgetting about Dick Van Dyke, he's like 97 and still going."
"If you've never heard of him, he played in Marry Poppins, along with a bunch more movies"- Longjumping_Drag2752
And Still Stunning
"Sophia Loren is still kicking."- The_REAL_McWeasel
Continuing To Go Where No Man Has Gone Before
"William Shatner doesn't look it but that dude is in his 90s wtf."- flubberF*ckWilliam Shatner Fun GIF by Shark WeekGiphy
Perhaps what's most admirable, is that even when these astonishing people do eventually pass, they will continue to live on and change the world with the remarkable work they did.
We all indulge in fast food from time to time.
Even if we know what we're eating isn't exactly healthy, sometimes the salty, fatty mass-produced food is the only thing we want.
Resulting in our making weekly, if not daily, visits to a nearby chain.
Then, of course, there are the chains that we make every effort to avoid.
We've likely tried places at least once simply because everyone is always talking about them.
But after having one bite, we have trouble seeing exactly what all the fuss was about and vow to never return.
Even if it might be the only option at a rest stop or even the only available food for miles, we instead opt to wait and be hungry.
Redditor BungOnMimosas was curious to hear what people considered to be the most overhyped fast food chains around, leading them to ask:
"What do you think are the most overrated fast-food chains? Why?"
"Food As It Should Be"... Or Not...
"I know it's not technically 'fast food', but Panera Bread pisses me off."
"Insanely expensive for extremely average food." - Reddit
"Their quality has decreased so much in the past few years and they’ve added weird sh*t to their menu like pizza and chicken sandwiches."
"Massive identity crisis and crap food."- asm233
Things Ain't What They Used To Be...
"All of them, now that they charge real restaurant prices."- P00pf4rt5
"As much as I hate to say it, McDonald's is the only place that I can think of that the quality hasn't changed much."
"I mean, that's a pretty low bar, but it is what it is."- gnatman66happy ronald mcdonald GIF by McDonald's CZ/SKGiphy
"The majority of them, especially the really big ones (McDonald's, Wendy's, BK, Pizza Hut, etc)."
"The prices are no longer fast food prices and the quality is not there like it used to be."
"Far better local options that cost roughly the same at the end of the day."- senorita_diablo
Consistency Is Key...
"You can go to the same location three separate times, have the food made by the same staff, and receive 3 wildly different results."- AndrewLampart
Not So Popular Anywhere, It seems...
"KFC in France became so bad."- SterBout
"KFC."- calm4ufried chicken animation GIF by octavioterolGiphy
Likely Won't Go National...
"Idk how wide spread they are, but in the Buffalo NY area there is a chain called Mighty Taco."
"They were even voted best tacos a few years ago."
"It is absolutely terrible food."
"I’ve tried to like it and given them 3 chances."
"Each time I couldn’t eat more than a couple bites."
"Absolutely terrible and I’m disgusted even thinking about their sour vomit in a tortilla."- aa-2020
"I think I’ve answered this question before but definitely for me, it’s Subway."
"Nothing but a giant hunk of bread."
"I’m editing this to add that part of my anger about Subway is how good it used to be."
"I can remember the days of nearly a whole can of tuna salad delicious sub."
"And a Veggie sub with Swiss cheese and piles of yummy veggies and the sweet Vidalia onion sauce."
"It’s all gone to sh*t."
"I would’ve been perfectly OK with increasing price but the big drop in quality pissed me off."
"Oh woe is me with my first world problems."- Mysterious-Region640football ok GIF by Subway ColombiaGiphy
Quantity Doesn't Guarantee Quality...
"Starbucks is a scam."- cmkeller62
Tasty, But Not Worth It...
"I’m going to say Five Guys."
"Not because the food isn’t good, but because I’m not paying $20 for a burger meal."- 2PacTookMyLunchMoney
"Dairy queen grill and Chill for sure."
"I worked at one for a lil' while and 1 burger combo is $14.56 CAD."- lolidk13Ice Cream Miracle Treat Day GIF by Children's Miracle Network HospitalsGiphy
And Not In A Good Way...
Big Kahuna Burger, it kills you."-Darklock2022
No two people have the same taste in food.
Some people know to avoid crappy food, while others eat literally nothing else.
There are several movies I've watched so many times I think the viewings outnumber the days I've lived.
And much like a favorite tv series or movie, who wouldn't love to start again anew?
Experiencing that first time but with that feeling of... "I'm gonna love this forever."
We never appreciate the first time enough.
But that's life.
Warning: there are spoilers below.
Redditor Jacale1 wanted to discuss all the movies we wish we could experience new all over again, so they asked:
"What is one movie that you wish you could watch again for the first time?"
There are a lot of mystery movies I'd love to redo, just to figure out the killer sooner.
Gasps!Raining The Shawshank Redemption GIFGiphy
"The Shawshank Redemption."
"A great nominee. Will never forget gasping when that rock went through the poster, and again when the warden pushed his arm through and ripped it down.... wow."
Over and Over
"Edge of Tomorrow."
"Is it bad that I got enjoyment knowing Tom Cruise died a lot in that movie. Never on screen, but it happened. Over and over. I hate that guy. How the hell was he the same height as Nichole Kidman in the movies they acted in together. Rhetorical question."
"Honestly the whole reason I watched the movie to begin with is that he kept dying over and over."
“'Stardust'- if you don’t know you’ll never know."
"I’m surprised that a fantasy romcom can be so enjoyable, for a straight guy. It’s just the right balance between fantasy, comedy, drama, and romance. Most of the female cast are very easy on the eyes too."
"I swooned when Yvaine glows while dancing on the ship, and when she talks emphatically to the mouse in the caravan. This movie has a lot of A listers, and they deliver. I’m not gonna lie, I have probably watched it half a dozen times."
"The book has so much more in it, even having seen the movie you'll feel like a child again."
"I watched this with my wife, who has never seen it, and that's about as close as you can get to watching it for the first time. It really displayed just how good the movie is. Also I love Aliens just as much for different reasons."
"Came here looking for this! I watched it for the first time with my dad when I was 11, and it’s one of my favorite childhood memories. Amazing movie."
Hey Arnoldsci-fi GIFGiphy
"I first watched this as a kid when I knew Arnold was the good guy in movies, and I had not seen T1. I wish I watched T2 for the first time after having watched T1. The mall scene would have been even more mind blowing."
T2 was definitely bada**!! I'd redo that.
"Bro, I'll go further. If I could watch the Nicholson covered in blood scene or the final scene between Damon and Wahlberg, I would be so freaking happy. The sheer acting clout on display for the first is near a masterclass while the last scene was just so business like, I'd love to relive that scene with fresh eyes. I love this freaking movie."
"The original Star Wars. Man, that blew our minds! It totally changed movies from then on. We'd never seen such incredible special effects. The story was so fun and the experience was amazing."
"Even though I’m not a franchise fan, I can get behind this answer. Because when I saw it first run, I was fourteen, and nothing like it had ever been done. I think it was the first movie where the special effects were the movie? Now that’s standard. It’s a reason people see many films now."
"So, for sheer originality, I’d watch it again, but only for the first time. I barely recall the second movie."
"The 6th Sense. I audibly gasped in the theater. All the clues are obvious on rewatch but that first time, before anyone knew M. Knight Shyamalan was a twist guy... wow."
"I never got to see it the first time. My girlfriend at the time (now wife) inadvertently let slip the ending thinking I had already seen it. I have never seen the point in watching it knowing the ending. But I did enjoy The Village."
"I watched it again and it was more of a sad film than a thriller."
"Spirited Away. I was blown away by how beautiful and bonkers it is."
"Saaaaame! Every single Studio Ghibli film, but Spirited Away especially! I’ve still watched it a million times though, and it’s always special. If I’m in a bad mood that film always cheers me up!"
"Also, Avatar-the last air bender. I know it’s not a movie, but I felt like it deserved a mention. I’ve watched the whole thing several times, and it’s always great, but I do wish I could forget it and rewatch it. I’m 35 btw... lol."
Great Scott!Doc Brown Shock GIF by Back to the Future TrilogyGiphy
"Back to the Future."
"I'd love to watch that in the cinemas... Now from the future."
Now I want to go to the movies.
There is no one way to anybody's heart or libido.
Sexy doesn't always have to equal raunchy.
I've known people turned on by music, books, nature, and even funerals (don't ask).
What starts someone's engine is a mystery.
Redditor asexyjohn18 wanted to hear about all the things that get people in the mood, so they asked:
"What is a non sexual trait that turns you on?"
I love a walk. A little strut. Nothing like getting the heart racing.
Tingleshair GIF by SB NationGiphy
"Getting my head scratched or having someone run their fingers through my hair."
"Same. It’s so pleasant when the tingles run down your spine... ;-) "
"When a girl genuinely laughs at jokes I make."
"I remember being on a first date with a beautiful woman and I made a bit of corny joke/comment and she laughed at it. I remember thinking, damn, wait till I get to my good stuff. I did get to my good material apparently as we were married. She gives me as many laughs as I give her."
"Kindness. When I see someone going out of their way to help others for no other reason than it’s the right thing to do… that is some truly attractive vibes."
"Apparently it's vanishing from this world really fast. People who show kindness often end up in losses (of course not everytime but most of the time yes). It really breaks my heart."
"Probably the sexiest thing out there. Someone can be smoking hot, funny, talented, etc. But if they're not kind, they're unattractive."
"Smiling right at me, and men stretching. LAWD HAVE MERCY!!"
"I have trouble smiling at women. Is this a turnoff for them? And ones I like are really hard to smile at. Because I know it's always going to be some really weird big smile if I am crushing which makes me feel like a super duper creep."
SimplicityHappy I Love You GIF by Warner Bros. DeutschlandGiphy
"Sorry if this is too kinky but i like it when they care about me."
"Too far man. You need to rethink your choices."
Sometimes it's all about the heart.
Eye 2 Eyei see you GIF by VH1Giphy
"When a guy explains something to you in a calm and understanding voice. Bonus points for gentle eye contact."
"Being crazily intelligent. Screw dirty talk, I want you to explain some unexplainable s**t in my ear."
"Heck yes. My best connections have been with a philosophy/history professor turned chancellor, an environmental engineer, and a neurosurgeon, all 3 Summa cum laude grads and conference speakers in their fields. The downside to genius though is complete absorption in their fields leaving little time for in person connection."
"Everyone should know how to cook. Hunger knows no gender. I like to eat good food so I learned how to cook. I asked my mom one day and she reacted surprised. She was more than grateful to have an opportunity to teach me the ‘finer’ aspects of cooking, as she called it. Lol. I love food."
"My girlfriend, now wife, likes to jokingly say I got her into bed with a well seasoned steak and homemade fries. I mean we did sleep together almost immediately after we finished dinner so maybe she’s right. That old saying comes to mind. 'The quickest way to the heart is though the stomach.'"
"When I ask my husband for help when I repot my plants and he delicately cleans and moves the leaves. He is a mechanical engineer and he works with huge pieces of industrial equipment, seeing him so tenderly caring for my plants just makes me melt."
Limbs A LotExcited Thomas Lennon GIF by ABC NetworkGiphy
"Men doing intricate work with their hands."
"I second this, also someone who can play guitar/bass real real well... just watching their hands, whoa mama."
Well, it seems that just about anything can get someone in the mood, especially if you're kind, courteous, and especially a good cook.
Anything to add? Let us know in the comments below!